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Damage to the nervous system is a predicted adverse effect arising from injury to microtubule-operated axonal transport mechanisms. Paclitaxel, from the bark of the pacific yew (Taxus brevifolia), inhibits disassembly of microtubules and induces atypical ones. Docetaxel is a semisynthetic derivative. Inhibition of DNA and RNA synthesis (A).
Counter-regulation in acute hypotension due to vasodilators (B). Increased sympathetic drive raises heart rate (reflex tachycardia) and cardiac output and thus helps to elevate blood pressure. Patients experience palpitations. Activation of the renin-angiotensin- aldosterone (RAA) system serves to increase blood volume, hence cardiac output. |
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