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Massive use of diuretics entails a hazard of adverse effects (A): (1) the decrease in blood volume can lead to hypotension and collapse; (2) blood viscosity rises due to the increase in erythro- and thrombocyte concentration, bringing an increased risk of intravascular coagulation or thrombosis.
At higher concentrations, nicotine acts to block ganglionic transmission. Simultaneous activation of many nicotinic cholinoceptors depolarizes the ganglionic cell membrane to such an extent that generation of action potentials is no longer possible, even in the face of an intensive and synchronized release of ACh (C).

 

Drug resistance is accelerating in many endemic areas; malaria vaccines may hold the greatest hope for control of infection. A tumor (neoplasm) consists of cells that proliferate independently of the body’s inherent “building plan.”
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