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Outlook: Cyclooxygenase (COX) has two isozymes: COX-1, a constitutive form present in stomach and kidney; and COX-2, which is induced in inflammatory cells in response to appropriate stimuli. Presently available NSAIDs inhibit both isozymes. The search for COX-2-selective agents (Celecoxib, Rofecoxib) is intensifying because, in theory, these ought to be tolerated better.
Arterial hypertension (high blood pressure) generally does not impair the well-being of the affected individual; however, in the long term it leads to vascular damage and secondary complications (A). The aim of antihypertensive therapy is to prevent the latter and, thus, to prolong life expectancy.

 

Wound disinfection can be achieved with hydrogen peroxide (0. 3%–1% solution; short, foaming action on contact with blood and thus wound cleansing) or with potassium permanganate (0. 0015% solution, slightly astringent), as well as PVP iodine, chlorhexidine, and biguanidines.
Presumably, it acts as a spindle poison to inhibit fungal mitosis. Although targeted against local mycoses, griseofulvin must be used systemically. It is incorporated into newly formed keratin. “Impregnated” in this manner, keratin becomes unsuitable as a fungal nutrient.

 

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