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Outlook: Cyclooxygenase (COX) has two isozymes: COX-1, a constitutive form present in stomach and kidney; and COX-2, which is induced in inflammatory cells in response to appropriate stimuli. Presently available NSAIDs inhibit both isozymes. The search for COX-2-selective agents (Celecoxib, Rofecoxib) is intensifying because, in theory, these ought to be tolerated better.
Wound disinfection can be achieved with hydrogen peroxide (0. 3%–1% solution; short, foaming action on contact with blood and thus wound cleansing) or with potassium permanganate (0. 0015% solution, slightly astringent), as well as PVP iodine, chlorhexidine, and biguanidines. |
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