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Bacitracin is a polypeptide mixture, markedly nephrotoxic and used only topically. Vancomycin is a glycopeptide and the drug of choice for the (oral) treatment of bowel inflammations occurring as a complication of antibiotic therapy (pseudomembranous enterocolitis caused by Clostridium difficile). It is not absorbed.
Altered activity of transport systems affects cell function (e.g., cardiac glycosides; loop diuretics; calcium-antagonists). Drugs may also directly interfere with intracellular metabolic processes, for instance by inhibiting (phosphodiesterase inhibitors) or activating (organic nitrates) an enzyme.

 

Salmeterol is a long-acting inhalative ?2-mimetic (duration: 12 h; onset ~20 min) that offers the advantage of a lower systemic exposure. It is used prophylactically at bedtime for nocturnal asthma.
Sulfonamides are produced by chemical synthesis. The basic structure is shown in (A). Residue R determines the pharmacokinetic properties of a given sulfonamide. Most sulfonamides are well absorbed via the enteral route. They are metabolized to varying degrees and eliminated through the kidney. Rates of elimination, hence duration of effect, may vary widely.

 

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