Drug Name Metformin

Compared with thioamides, its therapeutic importance is low but it is used as an adjunct in scintigraphic imaging of bone by means of technetate when accumulation in the thyroid gland has to be blocked. Short-term thyroid suppression (C). Iodine in high dosage (>6000 ?g/d) exerts a transient “thyrostatic” effect in hyperthyroid, but usually not in euthyroid, individuals.
Only drugs bearing sufficient resemblance to the physiological substrate of a carrier will exhibit affinity for it. Finally, membrane penetration may occur in the form of small membrane- covered vesicles. Two different systems are considered. Transcytosis (vesicular transport, C).

 

Even when the swallowed portion of an inhaled drug is absorbed in unchanged form, administration by this route has the advantage that drug concentrations at the bronchi will be higher than in other organs. The efficiency of mucociliary transport depends on the force of kinociliary motion and the viscosity of bronchial mucus.
Vit. D hormone promotes enteral absorption and renal reabsorption of Ca2+ and phosphate. As a result of the increased Ca2+ and phosphate concentration in blood, there is an increased tendency for these ions to be deposited in bone in the form of hydroxyapatite crystals. In vit. D deficiency, bone mineralization is inadequate (rickets, osteomalacia).