Drug Name Elavil

Therapeutic measures include: 1. administration of atropine in high dosage to shield muscarinic acetylcholine receptors; and 2. reactivation of acetylcholinesterase by obidoxime, which successively binds to the enzyme, captures the phosphate residue by a nucleophilic attack, and then dissociates from the active center to release the enzyme from inhibition.
Its congener, dihydroergotamine, is furthermore employed in orthostatic complaints. Other lysergic acid derivatives are the 5-HT antagonist methysergide, the dopamine agonists bromocriptine, pergolide, and cabergolide, and the hallucinogen lysergic acid diethylamide (LSD).

 

A peculiar type of damage results from the synthetic estrogenic agent, diethylstilbestrol, following its use during pregnancy; daughters of treated mothers have an increased incidence of cervical and vaginal carcinoma at the age of approx. 20.
Compared with whole blood or plasma, plasma substitutes offer several advantages: they can be produced more easily and at lower cost, have a longer shelf life, and are free of pathogens such as hepatitis B or C or AIDS viruses. Three colloids are currently employed as plasma volume expanders— the two polysaccharides, dextran and hydroxyethyl starch, as well as the polypeptide, gelatin.