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Inhibition of the enzymes involved in dopamine degradation, catecholamine-oxygen-methyl-transferase (COMT) and monoamineoxidase (MAO), is another means to increase actual available dopamine concentration (COMT-inhibitors), MAOB-inhibitors. Dopamine antagonist activity is the hallmark of classical neuroleptics.
In the respiratory tract, cilia-bearing epithelial cells are also joined on the luminal side by zonulae occludentes, so that the bronchial space and the interstitium are separated by a continuous phospholipid barrier. With sublingual or buccal application, a drug encounters the non-keratinized, multilayered squamous epithelium of the oral mucosa.

 

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Naltrexone may be used as an adjunct in withdrawal therapy. Buprenorphine behaves like a partial agonist/antagonist at ?-receptors. Pentazocine is an antagonist at ?-receptors and an agonist at ?-receptors (A). Both are classified as “low-ceiling” opioids (B), because neither is capable of eliciting the maximal analgesic effect obtained with morphine or meperidine.

 

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