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This condition is accompanied by a reduction in intestinal peristalsis (bowel atonia). The affected individual infers “constipation,” again partakes of the purgative, and the vicious circle is closed (2).
This effect is mediated by D1 receptors and is utilized in the treatment of cardiovascular shock and hypertensive emergencies by infusion of dopamine and fenoldopam, respectively. At higher doses, ?1-adrenoceptors and, finally, ?-receptors are activated, as evidenced by cardiac stimulation and vasoconstriction, respectively. |
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