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Conversely, most of the psychotomimetic effects are annulled by neuroleptics having 5-HT2A antagonist activity (e. g. clozapine, risperidone).
The structures of other agents such as tetrahydrocannabinol (from the hemp plant, Cannabis sativa— hashish, marihuana), muscimol (from the fly agaric, Amanita muscaria), or phencyclidine (formerly used as an injectable general anesthetic) do not reveal a similar connection.

 

The letters following PG (D, E, F, G, H, or I) indicate differences in substitution with hydroxyl or keto groups; the number subscripts refer to the number of double bonds, and the Greek letter designates the position of the hydroxyl group at C9 (the substance shown is PGF2?). PG are primarily inactivated by the enzyme 15- hydroxyprostaglandindehydrogenase.
Personality changes and paradoxical excitement are potential side effects. Clomethiazole can also be effective for controlling status epilepticus, but is used mainly to treat agitated states, especially alcoholic delirium tremens and associated seizures.

 

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