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One drug may displace another from its binding site and thereby elevate the free (effective) concentration of the displaced drug (a form of drug interaction). Elevation of the free concentration of the displaced drug means increased effectiveness and ccelerated elimination.
Intermediate insulin preparations (NPH or isophane, lente or zinc insulin) act for 18 to 26 h, slow preparations (protamine zinc insulin, ultralente or extended zinc insulin) for up to 36 h. Combination preparations contain insulin mixtures in solution and in suspension (e. g. , ultralente); the plasma concentration-time curve represents the sum of the two components. |
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