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Because the newly formed reductase is inhibited, too, the hepatocyte must meet its cholesterol demand by uptake of LDL from the blood (B). Accordingly, the concentration of circulating LDL decreases, while its hepatic clearance from plasma increases. There is also a decreased likelihood of LDL being oxidized into its proatheroslerotic degradation product.
Thiazide diuretics are potentially well suited in hypertension associated with congestive heart failure; however, they would be unsuitable in hypokalemic states. When hypertension is accompanied by angina pectoris, the preferred choice would be a ?-blocker or calcium antagonist rather than a diuretic. |
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